Product Name :
BQCA
Description:
BQCA a highly selective allosteric modulator of the M1 mAChR.
CAS:
338747-41-4
Molecular Weight:
309.32
Formula:
C18H15NO4
Chemical Name:
1-[(4-methoxyphenyl)methyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Smiles :
COC1C=CC(CN2C=C(C(O)=O)C(=O)C3C=CC=CC2=3)=CC=1
InChiKey:
BZBBTGCKPRSPGF-UHFFFAOYSA-N
InChi :
InChI=1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sacituzumab govitecan} site|{Sacituzumab govitecan} Antibody-drug Conjugate/ADC Related|{Sacituzumab govitecan} Biological Activity|{Sacituzumab govitecan} Formula|{Sacituzumab govitecan} manufacturer|{Sacituzumab govitecan} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BQCA a highly selective allosteric modulator of the M1 mAChR.|Product information|CAS Number: 338747-41-4|Molecular Weight: 309.32|Formula: C18H15NO4|Chemical Name: 1-[(4-methoxyphenyl)methyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|Smiles: COC1C=CC(CN2C=C(C(O)=O)C(=O)C3C=CC=CC2=3)=CC=1|InChiKey: BZBBTGCKPRSPGF-UHFFFAOYSA-N|InChi: InChI=1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5.45 mg/mL (17.62 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Wogonin} medchemexpress|{Wogonin} Autophagy|{Wogonin} Purity & Documentation|{Wogonin} Formula|{Wogonin} custom synthesis|{Wogonin} Epigenetics} |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23618405 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BQCA reduces the concentration of ACh required to activate M1 up to 129-fold with an inflection point value of 845 nM. No potentiation, agonism, or antagonism activity on other mAChRs is observed up to 100 μM. BQCA increases M1 receptor affinity for acetylcholine. The activation of the M1 receptor by BQCA induces a robust inward current and increases spontaneous excitatory postsynaptic currents in medial prefrontal cortex (mPFC) pyramidal cells.|In Vivo:|BQCA requires M1 to promote inositol phosphate turnover in primary neurons and to increase c-fos and arc RNA expression and ERK phosphorylation in the brain. BQCA reverses scopolamine-induced memory deficits in contextual fear conditioning, increases blood flow to the cerebral cortex, and increases wakefulness while reducing delta sleep. BQCA induces β-arrestin recruitment to M1, suggesting a role for this signal transduction mechanism in the cholinergic modulation of memory. BQCA increases firing of mPFC pyramidal cells in vivo. BQCA also restores discrimination reversal learning in a transgenic mouse model of Alzheimer’s disease.|Products are for research use only. Not for human use.|
