anti-β-hydroxybutyryllysine antibody conjugated agarose beads

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Anti-β-Hydroxybutyryllysine Antibody Conjugated Agarose Beads Clone Number: / Host: / Clonality: / Applications： IAP Reactivity: All Synonyms: Kbhb Product Size 500 μl ADD TO CART BUY NOW Quantity Shipping: Cold packs / dry ice Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Agarose Synonyms Kbhb UniProt ID / Immunogen β-Hydroxybutylated lysine peptides MW (kDa) Multiple Specificity With the immobilization of highly specific anti-β-hydroxybutyryllysine antibodies, the Anti-β-Hydroxybutyryllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing β-hydroxybutyryllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine β-hydroxybutyrylation. Product Usage Information Applications Dilution Recommended Species IAP 40 μl beads per 2 mg peptides All Properties Purity / Constituents Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody. Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt. Target Information Background Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia. Cellular location / Images Dot Blot Dot blot analysis of Anti-β-Hydroxybutyryllysine Rabbit pAb ( :
Anti-β-Hydroxybutyryllysine Antibody Conjugated Agarose Beads Clone Number: / Host: / Clonality: / Applications： IAP Reactivity: All Synonyms: Kbhb Product Size 500 μl ADD TO CART BUY NOW Quantity Shipping: Cold packs / dry ice Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Agarose Synonyms Kbhb UniProt ID / Immunogen β-Hydroxybutylated lysine peptides MW (kDa) Multiple Specificity With the immobilization of highly specific anti-β-hydroxybutyryllysine antibodies, the Anti-β-Hydroxybutyryllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing β-hydroxybutyryllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine β-hydroxybutyrylation. Product Usage Information Applications Dilution Recommended Species IAP 40 μl beads per 2 mg peptides All Properties Purity / Constituents Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody. Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt. Target Information Background Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia. Cellular location / Images Dot Blot Dot blot analysis of Anti-β-Hydroxybutyryllysine Rabbit pAb (