anti-mek3 rabbit mab

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Recombinant Rabbit Monoclonal Anti-MEK3 Rabbit mAb Clone Number: JRMR-10981-6 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human, Mouse, Rat Synonyms: MAPKK3, SAPKK2 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms MAPKK3, SAPKK2 UniProt ID P46734 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Human, Mouse, Rat Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background MAP2K3 encodes the mitogen-activated protein kinase 3 (MEK3) belonging to the mitogen-activated protein kinase (MAPK) signaling pathway. Dysregulation of the MAPK pathway is frequently observed in various cancers. MEK3 is a dual-specificity kinase that belongs to the MAPKK family responsible for the phosphorylation of serine/threonine and tyrosine residues of downstream MAPK substrates. Critical to the MAPK p38 signaling pathway, MEK3 and MEK6 activate p38 to induce cellular differentiation, migration, survival, apoptosis, and metabolism. Mice lacking MEK3 and MEK6 are more likely to develop cancer than their wild-type counterparts. Similarly, MEK3 expression is often downregulated in breast, colon, liver, esophageal squamous cell carcinoma, and thyroid cancer. Furthermore, inhibition of p38 is associated with resistance to therapy in hematopoietic malignancies. Cellular location Nucleus, Cytosol Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hoursat room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L(HRP Conjugate) Lysate: 1: HeLa, 2: HepG2, 3: C6, 4: NIH/3T3Protein loading quantity: 20 μg Exposure time: 30 secondsPredicted band size: 39 kDa Observed band size: 36, 39 kDa :
Recombinant Rabbit Monoclonal Anti-MEK3 Rabbit mAb Clone Number: JRMR-10981-6 Host: Rabbit Clonality: Recombinant Monoclonal Applications： WB Reactivity: Human, Mouse, Rat Synonyms: MAPKK3, SAPKK2 Product Size 100 μl ADD TO CART BUY NOW Quantity Shipping: Ambient temperature Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Unconjugated Synonyms MAPKK3, SAPKK2 UniProt ID P46734 Immunogen MW (kDa) Specificity Product Usage Information Applications Dilution Recommended Species WB 1:500 – 1:1000 Human, Mouse, Rat Properties Purity Protein A purified Constituents PBS, Glycerol, BSA Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt/reconstitution. Target Information Background MAP2K3 encodes the mitogen-activated protein kinase 3 (MEK3) belonging to the mitogen-activated protein kinase (MAPK) signaling pathway. Dysregulation of the MAPK pathway is frequently observed in various cancers. MEK3 is a dual-specificity kinase that belongs to the MAPKK family responsible for the phosphorylation of serine/threonine and tyrosine residues of downstream MAPK substrates. Critical to the MAPK p38 signaling pathway, MEK3 and MEK6 activate p38 to induce cellular differentiation, migration, survival, apoptosis, and metabolism. Mice lacking MEK3 and MEK6 are more likely to develop cancer than their wild-type counterparts. Similarly, MEK3 expression is often downregulated in breast, colon, liver, esophageal squamous cell carcinoma, and thyroid cancer. Furthermore, inhibition of p38 is associated with resistance to therapy in hematopoietic malignancies. Cellular location Nucleus, Cytosol Images WB Blocking buffer: 5% NFDM/TBSTPrimary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hoursat room temperature Secondary Ab: Goat Anti-Rabbit IgGH&L(HRP Conjugate) Lysate: 1: HeLa, 2: HepG2, 3: C6, 4: NIH/3T3Protein loading quantity: 20 μg Exposure time: 30 secondsPredicted band size: 39 kDa Observed band size: 36, 39 kDa