anti-l-lactyllysine antibody conjugated agarose beads

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Recombinant Rabbit Monoclonal Anti-L-Lactyllysine Antibody Conjugated Agarose Beads Clone Number: / Host: Rabbit Clonality: / Applications： IAP Reactivity: All Synonyms: Kla Product Size 500μl ADD TO CART BUY NOW Quantity Shipping: Cold packs / Dry ice Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Agarose Synonyms Kla UniProt ID / Immunogen L-lactylated lysine peptides MW (kDa) Multiple Specificity With the immobilization of highly specific Anti-L-Lactyllysine Antibodies, the Anti-L-Lactyllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing L-lactyllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine lactylation. Product Usage Information Applications Dilution Recommended Species IAP 40 μl beads per 2 mg peptides All Properties Purity / Constituents Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody. Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt. Target Information Background Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones. Cellular location / Images Dot Blot Dot blot analysis of Anti-L-Lactyllysine Rabbit pAb ( :
Recombinant Rabbit Monoclonal Anti-L-Lactyllysine Antibody Conjugated Agarose Beads Clone Number: / Host: Rabbit Clonality: / Applications： IAP Reactivity: All Synonyms: Kla Product Size 500μl ADD TO CART BUY NOW Quantity Shipping: Cold packs / Dry ice Order online or send purchase order to [email protected] FAQ Technical Support Protocols General Information Product Usage Information Properties Target Information Images Recommended Products References BUY NOW General Information Isotype IgG Conjugate Agarose Synonyms Kla UniProt ID / Immunogen L-lactylated lysine peptides MW (kDa) Multiple Specificity With the immobilization of highly specific Anti-L-Lactyllysine Antibodies, the Anti-L-Lactyllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing L-lactyllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine lactylation. Product Usage Information Applications Dilution Recommended Species IAP 40 μl beads per 2 mg peptides All Properties Purity / Constituents Antibody conjugated agarose beads are supplied as a 50% slurry containing 66% glycerol and 4 mg/ml immobilized antibody. Storage Store at -20°C. Avoid freeze/thaw cycles. Stability Stable for 12 months from date of receipt. Target Information Background Lactate, previously recognized solely as an energy source and metabolic byproduct, has now emerged as a crucial player in cancer biology, especially within the scope of the Warburg effect and its intricate interplay with various cellular processes, including angiogenesis, hypoxia, polarization of macrophages, and T cell activation. Recent investigations have unveiled an unprecedented function of lactate in the realm of histone modification, specifically through lysine L-lactylation, which exerts regulatory control over gene expression. The extent and dynamics of this modification are highly reliant on lactate levels within the cellular microenvironment and can be modulated through the introduction of extracellular lactate in cultured cells or the stimulation of intracellular glycolysis. The acetyltransferase p300 is responsible for introducing lysine L-lactylation, while Class I histone deacetylases (HDAC 1-3) have been identified as an eraser of the lactylation marks on histones. Cellular location / Images Dot Blot Dot blot analysis of Anti-L-Lactyllysine Rabbit pAb (