Functions. Nat Rev Mol Cell Bio 2009, ten:72132. Ni CW, Hsieh HJ, Chao YJ, Wang DL: Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow. Am J Physiol-Cell Ph 2004, 287:C771 780. Tsai YC, Hsieh HJ, Liao F, Ni CW, Chao YJ, Hsieh CY, Wang DL: Laminar flow attenuates interferon-induced inflammatory responses in endothelial cells. Cardiovasc Res 2007, 74:49705. Murphy E, Kohr M, Sun J, Nguyen T, Steenbergen C: S-nitrosylation: A radical method to defend the heart. J Mol Cell Cardiol 2012, 52:56877.doi:10.1186/1423-0127-21-3 Cite this article as: Hsieh et al.: Shear-induced endothelial mechanotransduction: the interplay amongst reactive oxygen species (ROS) and nitric oxide (NO) as well as the pathophysiological implications. Journal of Biomedical Science 2014 21:three.
Pathophysiology/ComplicationsO R I G I N A L A R T I C L EFibroblast Growth Element 21 Levels in Young Healthful Females Show Day and Evening Variations and Are Elevated in Response to Short-Term Power Deprivation By way of a LeptinIndependent PathwayJOO-PIN FOO, MD1 KONSTANTINOS N. ARONIS, MD1,two JOHN P. CHAMBERLAND, BSC1,2 JASON PARUTHI, BSC1 HYUN-SEUK MOON, PHD1 CHRISTOS S. MANTZOROS,MD1,OBJECTIVEdFibroblast development aspect (FGF)-21 is definitely an endocrine aspect with potent metabolic effects. Its day ight patterns of secretion and/or its physiological response to energy deprivation and connection to absolutely free fatty acids (FFAs) and/or leptin remain to be fully elucidated. We aim to elucidate day ight pattern of FGF-21 levels and its connection to FFA, to assess no matter whether energy deprivation alters its circulating patterns, and to examine whether or not leptin may mediate these changes.4-Hydroxynonenal Study Design AND METHODSdSix healthful lean females had been studied for 72 h within a cross-over interventional study under three diverse conditions: on isocaloric diet and inside a fasting state with administration of either placebo or metreleptin in physiological replacement doses.Sephadex LH 20 Blood samples had been obtained hourly from eight:00 A.M. on day four until eight:00 A.M. on day 5. RESULTSdFGF-21 exhibited day ight variation pattern throughout the isocaloric fed state. Fasting substantially enhanced FGF-21 levels (P , 0.PMID:34816786 01) through a leptin-independent pathway. Day ight variation pattern in the fed state was lost on fasting. Leptin replacement inside the hypoleptinemic state restored approximate entropy of FGF-21 time series but did not alter circulating levels. FGF-21 levels had been closely cross-correlated with FFA levels in all 3 states. CONCLUSIONSdA day ight variation within the levels of FGF-21 exists in young lean females in the fed state. Power deprivation increases FGF-21 levels by way of a leptin-independent pathway. The interaction amongst FGF-21 and starvation-induced lipolysis, as indicated by its close crosscorrelations with FFA in both fed state and energy deprivation, requirements to be studied further. Diabetes Care 36:93542,Fibroblast development element (FGF)-21 is an endocrine aspect predominantly expressed in the liver (1) that acts as a potent regulator of glucose and lipid metabolism (2). FGF receptors are expressed in pancreatic b cells of adult mice, and dominant-negative mutations of the FGF receptors result in decreasednumber of b cells and development of diabetes (three). Administration of FGF-21 in rodents reduces plasma glucose and triglycerides to near-normal levels and improves insulin sensitivity independent of reduction in body weight and adiposity (2,4). In humans, FGF-21 is positively correlated with.
