Ylation of serine 262 and 356 within the repeat domain and is inhibited by phosphorylation inside the proline-rich domains. Mol Biol Cell 1999, ten(three):72740. 38. Busciglio J, Lorenzo A, Yeh J, Yankner BA: -Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995, 14:87988. 39. Avila J, P ez M, Lim F, G ez-Ramos A, Hern dez F, Lucas JJ: Tau in neurodegenerative diseases: tau phosphorylation and assembly. Neurotox Res 2004, 6(6):47782. 40. Gendron TF, Petrucelli L: The function of tau in neurodegeneration. Mol Neurodegener 2009, four:13. 41. Zheng WH, Bastianetto S, Mennicken F, Ma W, Kar S: Amyloid beta peptide induces tau phosphorylation and loss of cholinergic Brd Inhibitor review neurons in rat major septal cultures. Neuroscience 2002, 115(1):20111. 42. iNOS Activator review Drechsel DN, Hyman AA, Cobb MH, Kirschner MW: Modulation on the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell 1992, three(10):1141154. 43. Salinero O, Moreno-Flores MT, Ceballos ML, Wandosell F: beta-Amyloid peptide induced cytoskeletal reorganization in cultured astrocytes. Neurosci Res 1997, 47:21623. 44. Rapoport M, Dawson HN, Binder LI, Vitek MP, Ferreira A: Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A 2002, 99(9):6364369. 45. Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ: Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A 2011, 108(14):5819824. 46. Takashima A, Honda T, Yasutake K, Michel G, Murayama O, Murayama M, Ishiguro K, Yamaguchi H: Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (255) enhances phosphorylation of tau in hippocampal neurons. Neurosci Res 1998, 31(four):31723. 47. Johansson S, J sA, Vas ge M, Winblad B, Luthman J, Cowburn RF: Elevated tau phosphorylation at the Ser396 epitope right after amyloid beta-exposure in organotypic cultures. Neuroreport 2006, 17(9):90711. 48. Shimoke K, Sasaya H, Ikeuchi T: Evaluation on the function of nerve development aspect in promoting cell survival for the duration of endoplasmic reticulum pressure in PC12 cells. Strategies Enzymol 2011, 490:530. 49. Li L, Sengupta A, Haque N, Grundke-Igbal I, Igbal K: Memantine inhibits and reverses the Alzheimer form abnormal hyperphosphorylation of tau and connected neurodegeneration. FEBS Lett 2004, 566:26169. 50. Hu M, Schurdak ME, Puttfarcken PS, El Kouhen R, Gopalakrishnan M, Li J: High content material screen microscopy evaluation of A beta 1-42-induced neurite outgrowth reduction in rat principal cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands. Brain Res 2007, 1151:22735. 51. Liu X, Xu K, Yan M, Wang Y, Zheng X: Protective effects of galantamine against Ab-induced PC12 cell apoptosis by stopping mitochondrial dysfunction and endoplasmic reticulum tension. Neurochem Int 2010, 57:58899. 52. Kurz C, Ungerer I, Lipka U, Kirr S, Sch t T, Eckert A, Leuner K, M ler WE: The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide. Br J Pharmacol 2010, 160(2):24657.doi:ten.1186/s12929-014-0074-2 Cite this article as: Ostrovskaya et al.: Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model requires the attenuation of apoptosis and tau hyperphosphorylation. Journal of Biomedical Science 2014 21:74.
European Journal of Human Genetics (2014) 22,.
