He period from 1976 to 2018, the decrease of temperature extremes and cold waves, expressed by the 10 percentile and 5 percentile of continuous episodes for five days or extra, respectively, was shown [176]. 2. Supplies and Solutions A literature search was carried out utilizing electronic databases Web of Science, Pubmed, Science Direct, Scopus, and e-Library, Cholesteryl Linolenate Description focusing on peer-reviewed journal articles published in English and in Russian from 2000 to 2021. Hand searching of the applicable literature was also performed in relevant journals and bibliographies of integrated research. 3 conceptual categories had been used: “extremely hot weather”, “extremely cold weather”, and “human health”, revealing a total of 189 records. We were searching for the key words “heat wave”, “hot weather”, “high temperature”, and/or “cold wave”, “cold spell”, “coldAtmosphere 2021, 12,5 ofweather”, “extremely low temperatures”, and “human health”, “cardiovascular mortality”, “respiratory mortality”, “cardiovascular disease”, “respiratory disease”, “mental health”, or “ambulance calls”, and also looked for studies cited in the recognized articles. The papers with duplicate and overlapping outcomes have been excluded in the evaluation and were not incorporated into final table placed at the finish from the Final results section. Finally, the search identified 16 research that were selected for the review. We didn’t impose any restrictions on study design. three. Outcomes Very first, it was shown that heat (cold) waves had been primarily defined as periods with abnormally higher (low) temperatures compared to present values, typically combined with higher humidity (sturdy wind), which have an adverse effect on human body, expressed within a statistically considerable improve in mortality or morbidity [69,71,72,9301,10711]. Based on long-term investigation, it was determined that heat (cold) waves incorporate periods with an excess of your 97(three) percentile in the distribution of mean every day temperature in the summer time (winter) months [145,177]. This threshold value is included within the Methodological Suggestions of Russian Rospotrebnadzor [178]. In addition to the air temperature measured at a weather station, some papers examined the Thermal tension expressed when it comes to perceived temperature, i.e., the temperature adjusted for the complex influence of air humidity, wind, clouds and atmospheric stress on the human physique [179,180]. In papers [99,110,111] the bioclimatic indices for instance the Wind-Chill Index (WCI) [181], the Temperature-Humidity Index (HUM) [182], the Apparent Temperature (AT) by Steadman [183], the Physiologically Equivalent Temperature (PET) [184], the Universal Thermal Climate Index (UTCI) [185], are employed. It was suggested that to become known as a wave, the period with extreme deviations on the chosen indicator must last continuously for several consecutive days; in line with the (+)-Sparteine sulfate manufacturer duration criterion, the waves have been classified as short (duration from five to 7 days) and extended (from eight days and longer) [107,110]. When analyzing temperature waves, in addition to their duration, other indicators had been described: the wave intensity, i.e. the sum of degrees above (beneath) the base temperature [72]; the “wave fraction” defined as the ratio from the number of days within the wave towards the total variety of days with temperatures above (beneath) the temperature threshold, for heat and cold waves, respectively [94,99]; the time shift involving the starting of your wave and the influence on the human physique because the lagged effect [55,70,97,98,one hundred,101]. In add.