Product Name: a Synuclein (phospho Tyr125) Antibody
Species Reactivity: Human
Tested Applications: IF, WB
Applications: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
User Note:
Predicted Molecular Weight: 18 kDa
Immunogen: a-Synuclein (Phospho-Tyr125) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y (p) -E-M) derived from Human α-Synuclein.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Physical State: Liquid
CAS NO.: 75172-81-5
Product: Migalastat (hydrochloride)
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: PD1, NACP, PARK1, PARK4, CD135, FLK2, STK1, SYN, SYUA, alpha-synuclein
Accession NO.: NP_000336.1
Protein Ino: 4507109
Official Symbol: SNCA
Geneid: 6622
Background: SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons
PubMed ID:http://aac.asm.org/content/51/11/4181.abstract
