Product Name: IkB a (phospho Tyr42) Antibody
Species Reactivity: Mouse, Rat
Tested Applications: IHC
Applications: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
User Note:
Predicted Molecular Weight: 39 kDa
Immunogen: IkB-a (Phospho-Tyr42) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y (p) -E-Q) derived from Human IkappaB-α.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 4884-68-8
Product: Daprodustat
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IKBA, MAD-3, NFKBI, CDC2, CDC28A, CDKN1, P34CDC2, IKBA, NFKBIA,
Accession NO.: NP_065390.1
Protein Ino: 10092619
Official Symbol: NFKBIA
Geneid: 4792
Background: Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
PubMed ID:http://aac.asm.org/content/25/6/687.abstract
