Product Name: IL-24 Antibody
Species Reactivity: Gorilla, Human, Monkey
Tested Applications: Flow, IHC, WB
Applications: IL-24 antibody can be used in ELISA starting at 1:2500 – 1:10000, Western Blot starting at 1:250 – 1:1000, immunohistochemistry starting at 5 μg/mL, immunocytochemistry, and immunofluorescence starting at 1:100 – 1:500.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: IL – 24 antibody was raised against a portion of amino acids 100 – 150 of IL – 24 (Human).
Host Species: Rabbit
Purification: Protein G Column
Physical State: Liquid
CAS NO.: 20283-92-5
Product: LMI070
Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
Concentration:
Storage Conditions: Antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IL24, FISP, IL10B, IL-24, IL-4-induced secreted protein, Interleukin 24, Interleukin-24, Melanocyte-associated Mda-7, Mob-5, ST16, Mda-7, MDA7, MOB5, C49A
Accession NO.: Q13007
Protein Ino: 2497340
Official Symbol: IL24
Geneid: 11009
Background: Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
PubMed ID:http://aac.asm.org/content/26/3/388.abstract
