Product Name: IL-17RA Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 95 kDa Observed: 135 kDa
Immunogen: IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA.The immunogen is located within amino acids 150 – 200 of IL-17RA.
Host Species: Rabbit
Purification: IL-17RA Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 486-56-6
Product: SGC707
Buffer: IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: IL-17RA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IL-17RA Antibody: CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R, Interleukin-17 receptor A, IL-17 receptor A
Accession NO.: NP_055154
Protein Ino: 23238208
Official Symbol: IL17RA
Geneid: 23765
Background: IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).
PubMed ID:http://aac.asm.org/content/26/2/211.abstract
