Product Name: IL12_2 Antibody
Species Reactivity: Human
Tested Applications: IHC-P, WB
Applications: For FACS starting dilution is: 1:25For WB starting dilution is: 1:1000For IHC-P starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 97 kDa
Immunogen: This IL12_2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-783 amino acids from the C-terminal region of human IL12_2.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 463130
Product: LMK-235
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, IL-12RB2, IL12RB2
Accession NO.: Q99665
Protein Ino: 12229836
Official Symbol: IL12RB2
Geneid: 3595
Background: The protein encoded by this gene is a type I transmembraneprotein identified as a subunit of the interleukin 12 receptorcomplex. The coexpression of this and IL12RB1 proteins was shown tolead to the formation of high-affinity IL12 binding sites andreconstitution of IL12 dependent signaling. The expression of thisgene is up-regulated by interferon gamma in Th1 cells, and plays arole in Th1 cell differentiation. The up-regulation of this gene isfound to be associated with a number of infectious diseases, suchas Crohns disease and leprosy, which is thought to contribute tothe inflammatory response and host defense.
PubMed ID:http://aac.asm.org/content/26/5/683.abstract
