Product Name: IKKb Antibody [IKB355]
Species Reactivity: Human, Mouse
Tested Applications: WB
Applications: Western blot: 2-4 ug/mlProvided assay concentrations are suggestions only, IKKb antibody titration may be required for optimal results.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
Host Species: Mouse
Purification: Protein G purified antibody
Physical State: Liquid
CAS NO.: 58-71-9
Product: NSC305787 (hydrochloride)
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.5 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta
Accession NO.:
Protein Ino:
Official Symbol: IKBKB
Geneid: 3551
Background: NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
PubMed ID:http://aac.asm.org/content/26/1/1.abstract
