Product Name: IKK epsilon Antibody
Species Reactivity: Human
Tested Applications: ELISA, IHC-P, WB
Applications: IKK epsilon antibody can be used for detection of IKK epsilon by Western blot at 1 μg/mL. An 80 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 80 kDa
Immunogen: IKK epsilon antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IKK epsilon.The immunogen is located within the last 50 amino acids of IKK epsilon.
Host Species: Rabbit
Purification: IKK epsilon Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 5321-32-4
Product: M1 receptor modulator
Buffer: IKK epsilon Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: IKK epsilon antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IKK epsilon Antibody: IKKE, IKKI, IKK-E, IKK-i, IKKE, KIAA0151, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Inducible I kappa-B kinase, I-kappa-B kinase epsilon
Accession NO.: AF241789
Protein Ino: 7288877
Official Symbol: IKBKE
Geneid: 9641
Background: IKK epsilon Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. IκB is phosphorylated by IκB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule in the IKK complex was recently identified and designated IKKε/IKK-i. IKK epsilon is required for the activation of NF-κB by PMA and T cell receptors but not by TNFα and IL-1. IKKε/IKK-i message is expressed in a variety of tissues and is inducible by TNFα, IL-1, and LPS.
PubMed ID:http://aac.asm.org/content/25/6/764.abstract
