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Product Name: IKK alpha Antibody
Species Reactivity: Human
Tested Applications: ELISA, ICC, IF, WB
Applications: IKK alpha can be used for detection of IKK alpha by Western blot at 1 μg/mL. An 85 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 85 kDa
Immunogen: IKK alpha antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IKK alpha.The immunogen is located within the last 50 amino acids of IKK alpha.
Host Species: Rabbit
Purification: IKK alpha Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 497836-10-9
Product: Ombrabulin (hydrochloride)
Buffer: IKK alpha Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: IKK alpha antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IKK alpha Antibody: IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase alpha
Accession NO.: AF009225
Protein Ino: 2327068
Official Symbol: CHUK
Geneid: 1147
Background: IKK alpha Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IkB-alpha. IKKα is expressed in variety of human tissues.
PubMed ID:http://aac.asm.org/content/25/6/747.abstract

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Author: Betaine hydrochloride