Product Name: IKBKB Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC, IP, WB
Applications: IKBKB antibody can be used in immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: IKKb peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Host Species: Rabbit
Purification: Delipidation and Defibrination
Physical State: Liquid
CAS NO.: 131179-95-8
Product: PI3Kα inhibitor 1
Buffer: 0.01% sodium azide.
Concentration:
Storage Conditions: Store IKBKB antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: IKBKB, Ikk 2, IKK-B, IKK2, IKKbeta, NFKBIKB, I-kappa-B kinase 2, IKKB, I-kappa-B-kinase beta, Ikb kinase-beta, IKK Beta, IKK-beta
Accession NO.: O14920
Protein Ino: 14285497
Official Symbol: IKBKB
Geneid: 3551
Background: NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFkB is negatively modulated by the inhibitory proteins IkB. In turn IkB is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate IkB leading to its degradation and the resulting translocation of NFkB to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF- a, endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.
PubMed ID:http://aac.asm.org/content/25/6/719.abstract