Product Name: IFNgamma Antibody [3F1E3]
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: Western Blot:1:500 – 1,000ELISA:Determining optimal working dilutions by titration test.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Ni-NTA purified recombinant human IFN-γ expressed in E. Coli strain BL21 (DE3).
Host Species: Mouse
Purification: Antibody is purified by protein A affinity chromatography.
Physical State:
CAS NO.: 965-52-6
Product: Artemotil
Buffer: Purified antibody in PBS containing 0.03% sodium azide
Concentration:
Storage Conditions: IFN-gamma monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: Immune interferon, IFN-gamma, IFG, IFI
Accession NO.: P01579
Protein Ino: 124479
Official Symbol: IFNG
Geneid: 3458
Background: Interferon-g (IFN-γ) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-γ strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.
PubMed ID:http://aac.asm.org/content/25/3/336.abstract
