Product Name: Hrk Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: Hrk antibody can be used for the detection of Hrk by Western blot at 2.5 – 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 10 kDa Observed: 12 kDa
Immunogen: HRK antibody was raised against a 15 amino acid synthetic peptide from near the center of human Hrk.The immunogen is located within the last 50 amino acids of Hrk.
Host Species: Rabbit
Purification: Hrk Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 575474-82-7
Product: 23-Hydroxybetulinic acid
Buffer: Hrk Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Hrk antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Hrk Antibody: DP5, HARAKIRI, BID3, Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3
Accession NO.: NP_003797
Protein Ino: 4504493
Official Symbol: HRK
Geneid: 8739
Background: Hrk Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
PubMed ID:http://aac.asm.org/content/23/6/932.abstract
