Product Name: HUS1 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 32 kDa
Immunogen: This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 260430-02-2
Product: GSK583
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Checkpoint protein HUS1, hHUS1, HUS1
Accession NO.: O60921
Protein Ino:
Official Symbol: HUS1
Geneid: 3364
Background: The protein encoded by this gene is a component of anevolutionarily conserved, genotoxin-activated checkpoint complexthat is involved in the cell cycle arrest in response to DNAdamage. This protein forms a heterotrimeric complex with checkpointproteins RAD9 and RAD1. In response to DNA damage, the trimericcomplex interacts with another protein complex consisting ofcheckpoint protein RAD17 and four small subunits of the replicationfactor C (RFC), which loads the combined complex onto thechromatin. The DNA damage induced chromatin binding has been shownto depend on the activation of the checkpoint kinase ATM, and isthought to be an early checkpoint signaling event. [provided byRefSeq].
PubMed ID:http://aac.asm.org/content/24/5/764.abstract
