Product Name: HNRNPH3 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 37 kDa
Immunogen: This HNRNPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the Central region of human HNRNPH3.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1420477-60-6
Product: CFI-400945 (free base)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Heterogeneous nuclear ribonucleoprotein H3, hnRNP H3, Heterogeneous nuclear ribonucleoprotein 2H9, hnRNP 2H9, HNRNPH3, HNRPH3
Accession NO.: P31942
Protein Ino: 23503095
Official Symbol: HNRNPH3
Geneid: 3189
Background: This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has tworepeats of quasi-RRM domains that bind to RNAs. It is localized innuclear bodies of the nucleus. This protein is involved in thesplicing process and it also participates in early heatshock-induced splicing arrest by transiently leaving the hnRNPcomplexes. Several alternatively spliced transcript variants havebeen noted for this gene, however, not all are fully characterized.
PubMed ID:http://aac.asm.org/content/23/3/416.abstract
