Product Name: HNRNPA1 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 39 kDa
Immunogen: This HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human HNRNPA1.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1661839-45-7
Product: Procyanidin B1
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
Accession NO.: P09651
Protein Ino: 288558857
Official Symbol: HNRNPA1
Geneid: 3178
Background: This gene belongs to the A/B subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has tworepeats of quasi-RRM domains that bind to RNAs. It is one of themost abundant core proteins of hnRNP complexes and it is localizedto the nucleoplasm. This protein, along with other hnRNP proteins,is exported from the nucleus, probably bound to mRNA, and isimmediately re-imported. Its M9 domain acts as both a nuclearlocalization and nuclear export signal. The encoded protein isinvolved in the packaging of pre-mRNA into hnRNP particles,transport of poly A+ mRNA from the nucleus to the cytoplasm, andmay modulate splice site selection. It is also thought have aprimary role in the formation of specific myometrial proteinspecies in parturition. Multiple alternatively spliced transcriptvariants have been found for this gene but only two transcripts arefully described. These variants have multiple alternativetranscription initiation sites and multiple polyA sites. [providedby RefSeq].
PubMed ID:http://aac.asm.org/content/23/3/374.abstract
