Product Name: HM13 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 41 kDa
Immunogen: This HM13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the C-terminal region of human HM13.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 108212-76-6
Product: OABK (hydrochloride)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.43 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Accession NO.: Q8TCT9
Protein Ino: 25008563
Official Symbol: HM13
Geneid: 81502
Background: The protein encoded by this gene, which localizes to theendoplasmic reticulum, catalyzes intramembrane proteolysis of somesignal peptides after they have been cleaved from a preprotein.This activity is required to generate signal sequence-derived humanlymphocyte antigen-E epitopes that are recognized by the immunesystem, and to process hepatitis C virus core protein. The encodedprotein is an integral membrane protein with sequence motifscharacteristic of the presenilin-type aspartic proteases. Multipletranscript variants encoding several different isoforms have beenfound for this gene.
PubMed ID:http://aac.asm.org/content/23/1/175.abstract
