Product Name: HLA-DQA1 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000For FACS starting dilution is: 1:10~50
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 28 kDa
Immunogen: This HLA-DQA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the N-terminal region of human HLA-DQA1.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 284661-68-3
Product: BMS 299897
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.4 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HLA class II histocompatibility antigen, DQ alpha 1 chain, DC-1 alpha chain, DC-alpha, HLA-DCA, MHC class II DQA1, HLA-DQA1
Accession NO.: P01909
Protein Ino: 122188
Official Symbol: HLA-DQA1
Geneid: 100509457, 3117
Background: HLA-DQA1 belongs to the HLA class II alpha chainparalogues. The class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane.It plays a central role in the immune system by presenting peptidesderived from extracellular proteins. Class II molecules areexpressed in antigen presenting cells (APC: B Lymphocytes,dendritic cells, macrophages). The alpha chain is approximately33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leaderpeptide, exons 2 and 3 encode the two extracellular domains, andexon 4 encodes the transmembrane domain and the cytoplasmic tail.Within the DQ molecule both the alpha chain and the beta chaincontain the polymorphisms specifying the peptide bindingspecificities, resulting in up to four different molecules. Typingfor these polymorphisms is routinely done for bone marrowtransplantation.
PubMed ID:http://aac.asm.org/content/23/1/46.abstract
