Product Name: HLA-DPA1 Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 29 kDa
Immunogen: This HLA-DPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids from the C-terminal region of human HLA-DPA1.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 160807-49-8
Product: MQAE
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.4 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1, HLA-DPA1, HLA-DP1A, HLASB
Accession NO.: P20036
Protein Ino: 122204
Official Symbol: HLA-DPA1
Geneid: 3113
Background: HLA-DPA1 belongs to the HLA class II alpha chainparalogues. This class II molecule is a heterodimer consisting ofan alpha (DPA) and a beta (DPB) chain, both anchored in themembrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class IImolecules are expressed in antigen presenting cells (APC: Blymphocytes, dendritic cells, macrophages). The alpha chain isapproximately 33-35 kDa and its gene contains 5 exons. Exon oneencodes the leader peptide, exons 2 and 3 encode the twoextracellular domains, exon 4 encodes the transmembrane domain andthe cytoplasmic tail. Within the DP molecule both the alpha chainand the beta chain contain the polymorphisms specifying the peptidebinding specificities, resulting in up to 4 different molecules.
PubMed ID:http://aac.asm.org/content/23/1/31.abstract
