Product Name: HLA-DMB Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 29 kDa
Immunogen: This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1629249-40-6
Product: Dipsacoside B
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7
Accession NO.: P28068
Protein Ino: 133160
Official Symbol: HLA-DMB
Geneid: 3109
Background: HLA-DMB belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha(DMA) and a beta (DMB) chain, both anchored in the membrane. It islocated in intracellular vesicles. DM plays a central role in thepeptide loading of MHC class II molecules by helping to release theCLIP (class II-associated invariant chain peptide) molecule fromthe peptide binding site. Class II molecules are expressed inantigen presenting cells (APC: B lymphocytes, dendritic cells,macrophages). The beta chain is approximately 26-28 kDa and itsgene contains 6 exons. Exon one encodes the leader peptide, exons 2and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail.
PubMed ID:http://aac.asm.org/content/23/1/22.abstract
