Product Name: HINT1 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, ICC, WB
Applications: HINT1 antibody can be used for detection of HINT1 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: HINT1 antibody was raised against a 17 amino acid synthetic peptide near the center of the human HINT1.The immunogen is located within the last 50 amino acids of HINT1.
Host Species: Rabbit
Purification: HINT1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1621523-07-6
Product: Chrysophanol
Buffer: HINT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: HINT1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HINT1 Antibody: HINT, NMAN, PKCI-1, PRKCNH1, HINT, PKCI1, Histidine triad nucleotide-binding protein 1, Protein kinase C inhibitor 1
Accession NO.: NP_005331
Protein Ino: 4885413
Official Symbol: HINT1
Geneid: 3094
Background: HINT1 Antibody: Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
PubMed ID:http://aac.asm.org/content/22/4/611.abstract
