Product Name: HIG2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: HIG2 antibody can be used for detection of HIG2 by Western blot at 1 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: HIG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human HIG2.The immunogen is located within the last 50 amino acids of HIG2.
Host Species: Rabbit
Purification: HIG2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1268454-23-4
Product: Paeonol
Buffer: HIG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: HIG2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HIG2 Antibody: RCF1b, HIG1 domain family member 2A, mitochondrial, RCF1 homolog B, RCF1b
Accession NO.: NP_001092256
Protein Ino: 20270389
Official Symbol: HIGD2A
Geneid: 192286
Background: HIG2 Antibody: HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.
PubMed ID:http://aac.asm.org/content/22/4/593.abstract
