Product Name: HHATL Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: HHATL antibody can be used for detection of HHATL by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: HHATL antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human HHATL.The immunogen is located within the first 50 amino acids of HHATL.
Host Species: Rabbit
Purification: HHATL Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1784751-18-3
Product: LY 344864 (S-enantiomer)
Buffer: HHATL Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: HHATL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HHATL Antibody: GUP1, OACT3, C3orf3, MBOAT3, MSTP002, GUP1, KIAA1173, Protein-cysteine N-palmitoyltransferase HHAT-like protein, Hedgehog acyltransferase-like protein
Accession NO.: NP_065758
Protein Ino: 239582769
Official Symbol: HHATL
Geneid: 57467
Background: HHATL Antibody: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.
PubMed ID:http://aac.asm.org/content/22/3/518.abstract
