Product Name: HDAC5 (Ab 498) Antibody
Species Reactivity: Human
Tested Applications: IHC, WB
Applications: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
User Note:
Predicted Molecular Weight: 124 kDa
Immunogen: HDAC5 (Ab-498) antibody was raised against a peptide sequence around aa.496~500 (T-Q-S-S-P) derived from Human HDAC5/7.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 1948-33-0
Product: Elacestrant (dihydrochloride)
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: HD5, NY-CO-9, CYK18, PIG46, HD5
Accession NO.: NP_001015053.1
Protein Ino: 62750349
Official Symbol: HDAC5
Geneid: 10014
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
PubMed ID:http://aac.asm.org/content/21/4/676.abstract
