Product Name: HCC-4 Antibody [LEC66]
Species Reactivity: Human
Tested Applications: ELISA, Func, WB
Applications: ELISA: order BSA-free format Functional testing: order BSA/azide free formatThe concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
User Note: Optimal dilutions for each application to be determined by the researcher
Predicted Molecular Weight:
Immunogen: Recombinant human protein was used as the immunogen for this LEC antibody.
Host Species: Mouse
Purification: Protein G purified
Physical State: Liquid
CAS NO.: 77-59-8
Product: 10074-G5
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Conditions: Aliquot and Store at -20C. Avoid freez-thaw cycles.
Clonality: Monoclonal
Conjugate: Unconjugated
Alternate Names: LEC, LMC, NCC4, CKb12, HCC-4, LCC-1, Mtn-1, NCC-4, SCYL4, ILINCK, SCYA16, C-C motif chemokine 16, Chemokine CC-4
Accession NO.:
Protein Ino:
Official Symbol: CCL16
Geneid: 6360
Background: LEC, also called HCC-4, shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelo-suppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant LEC shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. LEC (HCC-4) is predominantly expressed in liver, but also found in spleen and thymus. It is highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. The ability of LEC (HCC-4) to markedly improve recognition of poorly immunogenic cells suggests that it could be an effective component of anti-tumor vaccines.
PubMed ID:http://aac.asm.org/content/21/3/393.abstract
