Product Name: GRM5 Antibody
Species Reactivity: Bat, Bovine, Chicken, Dog, Gibbon, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Tested Applications: IHC
Applications: GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).
Host Species: Rabbit
Purification: Immunoaffinity Chromatography
Physical State: Liquid
CAS NO.: 848258-31-1
STING agonist-1
Buffer: PBS, 0.1% sodium azide.
Concentration:
Storage Conditions: GRM5 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: GRM5, GPRC1E, MGLUR5, Mglur5b, MGlu5
Accession NO.: P41594
Protein Ino: 1709020
Official Symbol: GRM5
Geneid: 2915
Background: Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia
PubMed ID:http://aac.asm.org/content/20/1/140.abstract
