Product Name: GRK6 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: GRK6 antibody can be used for detection of GRK6 by Western blot at 1 – 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 63 kDa Observed: 63 kDa
Immunogen: GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6.The immunogen is located within the last 50 amino acids of GRK6.
Host Species: Rabbit
Purification: GRK6 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 890128-81-1
Amcasertib
Buffer: GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: GRK6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: GRK6 Antibody: GPRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6
Accession NO.: NP_001004106
Protein Ino: 51896039
Official Symbol: GRK6
Geneid: 2870
Background: The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).
PubMed ID:http://aac.asm.org/content/20/1/109.abstract
