Product Name: C2CD3 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: C2CD3 antibody can be used for detection of C2CD3 by Western blot at 1 – 2 μg/ml.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 216, 259 kDa Observed: 255 kDa
Immunogen: C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3.The immunogen is located within amino acids 1490 – 1540 of C2CD3.
Host Species: Rabbit
Purification: C2CD3 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1351926-90-3
Product: T338C Src-IN-1
Buffer: C2CD3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: C2CD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: C2 calcium-dependent domain containing 3, C2 domain-containing protein 3
Accession NO.: NP_001273506
Protein Ino: 148596944
Official Symbol: C2CD3
Geneid: 26005
Background: C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1). It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3). C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5).
PubMed ID:http://aac.asm.org/content/42/10/2747.abstract
