Product Name: Bst2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: Bst2 antibody can be used for detection of Bst2 by Western blot at 1 – 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Bst2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of the mouse Bst2.The immunogen is located within amino acids 60 – 110 of Bst2.
Host Species: Rabbit
Purification: Bst2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1262888-28-7
Product: Spautin-1
Buffer: Bst2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Bst2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bst2 Antibody: GREG, Bst-2, CD317, C87040, DAMP-1, 2310015I10Rik, Bone marrow stromal antigen 2, BST-2
Accession NO.: AAH87949
Protein Ino: 56971124
Official Symbol: Bst2
Geneid: 69550
Background: Bst2 Antibody: Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.
PubMed ID:http://aac.asm.org/content/42/6/1424.abstract
