Product Name: Beta-Catenin (phospho Ser33 / Ser37)Antibody
Species Reactivity: Human, Mouse, Rat, Xenopus
Tested Applications: WB
Applications: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with mouse, rat and Xenopus based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 83
Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33, 37 of human beta-catenin.
Host Species: Rabbit
Purification: Affinity Purified
Physical State: Liquid
CAS NO.: 313-06-4
Product: Estradiol (cypionate)
Buffer: 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Concentration:
Storage Conditions: Beta-Catenin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: CTNNB, MRD19, armadillo, CTNNB
Accession NO.: P35222
Protein Ino: 461854
Official Symbol: CTNNB1
Geneid: 1499
Background: Beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of beta-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3beta (GSK3beta) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of beta-catenin. Mutations in components of this phosphorylation regulated process that prevent beta-catenin hyperphosphorylation by GSK3beta are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).
PubMed ID:http://aac.asm.org/content/42/2/464.abstract
