Product Name: Bcl-2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, IHC-P, WB
Applications: Bcl-2 antibody can be used for detection of Bcl-2 by Western blot at 1 to 2 μg/mL. Bcl-2 antibody can also detect Bcl-2 by immunohistochemistry at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 23, 26 kDa Observed: 26 kDa
Immunogen: Bcl-2 antibody was raised against a peptide corresponding to 15 amino acids near the N terminus of human Bcl-2.The immunogen is located within the first 50 amino acids of Bcl-2.
Host Species: Rabbit
Purification: Bcl-2 Antibody is Ion exchange chromatography purified.
Physical State: Liquid
CAS NO.: 50-50-0
Product: Estradiol (benzoate)
Buffer: Bcl-2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Bcl-2antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bcl-2 Antibody: Bcl-2, PPP1R50, Apoptosis regulator Bcl-2
Accession NO.: AAH27258
Protein Ino: 20072668
Official Symbol: BCL2
Geneid: 596
Background: Bcl-2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis. It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad. Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
PubMed ID:http://aac.asm.org/content/53/11/4921.abstract
