Product Name: Bcl-10 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, ICC, IF, WB
Applications: Bcl-10 antibody can be used for detection of BCL10 by Western blot at 0.5 μg/mL. dilution. An approximately 31 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 31 kDa
Immunogen: Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10.The immunogen is located within the first 50 amino acids of Bcl-10.
Host Species: Rabbit
Purification: Bcl-10 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 520-45-6
Product: Dehydroacetic acid
Buffer: Bcl-10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: Bcl-10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bcl-10 Antibody: CLAP, mE10, CIPER, c-E10, CARMEN, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10
Accession NO.: AF134395
Protein Ino: 5070371
Official Symbol: BCL10
Geneid: 8915
Background: Bcl-10 Antibody: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.
PubMed ID:http://aac.asm.org/content/53/11/4903.abstract
