Product Name: Bak Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, ICC, WB
Applications: Bak antibody can be used for detection of Bak by Western blot at 1 to 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.The immunogen is located within amino acids 30 – 80 of Bak.
Host Species: Rabbit
Purification: Bak Antibody is Ion exchange chromatography purified.
Physical State: Liquid
CAS NO.: 50-03-3
Product: Hydrocortisone (acetate)
Buffer: Bak Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Bak antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Bak Antibody: BAK, CDN1, BCL2L7, BAK-LIKE, BAK, Apoptosis regulator BAK, Bcl2-L-7
Accession NO.: Q16611
Protein Ino: 2493274
Official Symbol: BAK1
Geneid: 578
Background: Bak Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria. It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability.
PubMed ID:http://aac.asm.org/content/53/10/4457.abstract
