Product Name: BL-CAM (phospho Tyr807) Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 95 kDa
Immunogen: BL-CAM (phospho Tyr807) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y (p)-E-N) derived from Human BL-CAM.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 4547-24-4
Product: Corosolic acid
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Siglec-2, B-cell receptor CD22, BL-CAM, Leu-14, B-lymphocyte cell adhesion molecule
Accession NO.: NP_001762.2
Protein Ino: 157168355
Official Symbol: CD22
Geneid: 933
Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
PubMed ID:http://aac.asm.org/content/42/3/721.abstract
