Product Name: BLNK (phospho Tyr96) Antibody
Species Reactivity: Human, Mouse
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 50 kDa
Immunogen: BLNK (phospho Tyr96) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 96 (D-S-Y (p)-E-P) derived from Human BLNK .
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 2856-75-9
Product: Modaline (sulfate)
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: B-cell linker protein, LY57, SLP-65, SLP65,
Accession NO.: NM_001114094.1
Protein Ino: 7019535
Official Symbol: BLNK
Geneid: 29760
Background: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.
PubMed ID:http://aac.asm.org/content/42/3/571.abstract
