Product Name: BLK (phospho Tyr501) Antibody
Species Reactivity: Human, Mouse
Tested Applications: IHC
Applications:
User Note:
Predicted Molecular Weight: 57 kDa
Immunogen: BLK (phospho Tyr501) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y (p)-E-L) derived from Human BLK.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 110642-44-9
Product: Epmedin C
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: p55-BLK, EC 2.7.10.2, kinase Blk, B lymphocyte kinase, Tyrosine-protein kinase BLK
Accession NO.: NP_001706.2
Protein Ino: 33469982
Official Symbol: BLK
Geneid: 640
Background: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor.
PubMed ID:http://aac.asm.org/content/42/3/534.abstract
