Product Name: BCMA Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC-P, WB
Applications: BCMA antibody can be used for detection of BCMA by Western blot at 5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 20 kDa Observed: 27 kDa
Immunogen: BCMA antibody was raised against a 16 amino acid synthetic peptide mapping at the carboxy terminus of human BCMA.The immunogen is located within the last 50 amino acids of BCMA.
Host Species: Rabbit
Purification: BCMA Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 529-59-9
Product: Genistin
Buffer: BCMA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BCMA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BCMA Antibody: BCM, BCMA, CD269, TNFRSF13A, BCM, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein
Accession NO.: NP_001183
Protein Ino: 23238192
Official Symbol: TNFRSF17
Geneid: 608
Background: BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
PubMed ID:http://aac.asm.org/content/53/12/5114.abstract
