Product Name: BCL2A1 Antibody
Species Reactivity: Human
Tested Applications: ELISA, WB
Applications: BCL2A1 antibody can be used for detection of BCL2A1 by ELISA at 1:12500. BCL2A1 antibody can be used for detection of BCL2A1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 20 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BCL2A1.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 3736-81-0
Product: Diloxanide furoate
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store BCL2A1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BCL2A1, GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5
Accession NO.: NP_004040
Protein Ino: 4757840
Official Symbol: BCL2A1
Geneid: 597
Background: BCL2A1s a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
PubMed ID:http://aac.asm.org/content/53/12/5288.abstract
