Product Name: BCL10 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IHC, WB
Applications: BCL10 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: BCL10 antibody was raised against amino acids 5-19 of BCL10 (Human).
Host Species: Rabbit
Purification: Purified
Physical State: Liquid
CAS NO.: 406-90-6
Product: Fluroxene
Buffer: PBS, 0.02% sodium azide.
Concentration:
Storage Conditions: Store BCL10 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BCL10, Bcl-10, B-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, CARMEN, CARD-like apoptotic protein, CCARMEN, C-E10, CIPER, Cellular-E10, HCLAP, Cellular homolog of vCARMEN, CLAP, ME10
Accession NO.: O95999
Protein Ino: 20454813
Official Symbol: BCL10
Geneid: 8915
Background: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.
PubMed ID:http://aac.asm.org/content/53/12/5259.abstract
