Product Name: BCAR3 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, WB
Applications: BCAR3 antibody can be used for detection of BCAR3 by Western blot at 1 – 2 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 91 kDa
Immunogen: BCAR3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BCAR3.The immunogen is located within amino acids 30 – 80 of BCAR3.
Host Species: Rabbit
Purification: BCAR3 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 80-35-3
Product: Sulfamethoxypyridazine
Buffer: BCAR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BCAR3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BCAR3 Antibody: NSP2, SH2D3B, NSP2, UNQ271/PRO308, Breast cancer anti-estrogen resistance protein 3, Novel SH2-containing protein 2
Accession NO.: NP_003558
Protein Ino: 4502371
Official Symbol: BCAR3
Geneid: 8412
Background: BCAR3 Antibody: Breast cancer anti-estrogen resistance 3 (BCAR3) was identified in the search for genes involved in the development of estrogen resistance. It contains a putative src homology 2 (SH2) domain and is partly homologous to the cell division cycle protein CDC48. BCAR3 is a binding partner with Cas, an adapter molecule that plays a role in cell proliferation, survival, cell adhesion, and mobility. BCAR3 functions synergistically with Cas to enhance Src activation and promote cell migration, and has been suggested to regulate Cas/Src association, Src kinase activity, and breast cancer adhesion signaling.
PubMed ID:http://aac.asm.org/content/53/11/4794.abstract
