Product Name: BAP31 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IHC-P, WB
Applications: BAP31 antibody can be used for the detection of BAP31 by Western blot at 0.5 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: BAP31 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human BAP31.The immunogen is located within the last 50 amino acids of BAP31.
Host Species: Rabbit
Purification: BAP31 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 347379-29-7
Product: LTV-1
Buffer: BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BAP31 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BAP31 Antibody: CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31
Accession NO.: NP_005736
Protein Ino: 32171186
Official Symbol: BCAP31
Geneid: 10134
Background: BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.
PubMed ID:http://aac.asm.org/content/53/10/4514.abstract
