Product Name: BACE Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, ICC, IF, IHC-P, WB
Applications: BACE can be used for detection of BACE by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 70 kDa
Immunogen: BACE antibody was raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.The immunogen is located within the last 50 amino acids of BACE.
Host Species: Rabbit
Purification: BACE Antibody is Ion exchange chromatography purified.
Physical State: Liquid
CAS NO.: 1346242-81-6
Product: Erdafitinib
Buffer: BACE Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BACE antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BACE Antibody: ASP2, BACE, HSPC104, KIAA1149, Beta-secretase 1, Aspartyl protease 2, ASP2
Accession NO.: AF190725
Protein Ino: 6118538
Official Symbol: BACE1
Geneid: 23621
Background: BACE Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimers disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimers disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
PubMed ID:http://aac.asm.org/content/53/9/4035.abstract
