Product Name: BACE2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IHC-P, WB
Applications: BACE2 can be used for detection of BACE2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 57 kDa Observed: 66 kDa
Immunogen: BACE2 antibody was raised against a 16 amino acid peptide near the amino terminus of human BACE2.The immunogen is located within amino acids 30 – 80 of BACE2.
Host Species: Rabbit
Purification: BACE2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 142326-59-8
Product: L-701324
Buffer: BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: BACE2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BACE2 Antibody: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, UNQ418/PRO852, Beta-secretase 2, Aspartic-like protease 56 kDa, ASP1
Accession NO.: AAF17078
Protein Ino: 6561812
Official Symbol: BACE2
Geneid: 25825
Background: BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimers disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region, suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
PubMed ID:http://aac.asm.org/content/53/10/4080.abstract
