Product Name: BACE1 Antibody
Species Reactivity: Gibbon, Gorilla, Human, Monkey
Tested Applications: IHC
Applications: BACE1 antibody can be used in ELISA, Western Blot starting at 1:500 – 1:1000, and immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: BACE1 antibody was raised against a peptide located in the near N-Terminus of BACE1 (Human).
Host Species: Rabbit
Purification: Immunoaffinity Chromatography
Physical State: Liquid
CAS NO.: 486427-17-2
Product: CIQ
Buffer: PBS, 0.1% sodium azide.
Concentration:
Storage Conditions: BACE1 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2
Accession NO.: P56817
Protein Ino: 296434407
Official Symbol: BACE1
Geneid: 23621
Background: Bace 1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
PubMed ID:http://aac.asm.org/content/53/10/4064.abstract
