Product Name: Anthrax Protective Antigen Antibody
Species Reactivity: Bacteria
Tested Applications: ELISA
Applications: Anthrax protective antigen antibody can be used for the detection of Anthrax protective antigen protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Anthrax protective antigen antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of the Anthrax protective antigen protein.The immunogen is located within amino acids 600 – 650 of Anthrax Protective Antigen.
Host Species: Rabbit
Purification: Anthrax Protective Antigen Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 19130-96-2
Product: 1-Deoxynojirimycin
Buffer: Anthrax Protective Antigen Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Anthrax Protective Antigen antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Anthrax Protective Antigen Antibody: pag, pXO1-110, BXA0164, GBAA_pXO1_0164, Protective antigen, Anthrax toxins translocating protein, PA
Accession NO.: AAF86457
Protein Ino: 9280533
Official Symbol: pxo1_110
Geneid: 3361714
Background: Anthrax Protective Antigen Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
PubMed ID:http://aac.asm.org/content/53/1/295.abstract
